Dadimadi yoga, a compound Ayurvedic formulation was evaluated for haematinic activity against mercuric chloride induced anemia. Eighteen adult Charles Foster strain albino rats of either sex were divided in to three groups, first group received distilled water and served as control, second group rats were administered with mercuric chloride (9 mg/kg) and served as negative control. To the third group, Dadimadi yoga and mercuric chloride were administered for thirty consecutive days. Parameters like body weight, weight of liver, spleen and kidney, different haematological parameters, anemia markers like serum iron, serum ferritin, total iron binding capacity (TIBC) and histopathology of liver, kidney and spleen were studied. Exposure of mercuric chloride to rats for 30 days resulted in decrease of body weight, increase in weight of spleen, liver and kidney, decrease in haemoglobin content, total RBC and haematocrit percentage. It also decreased serum iron and serum ferritin to significant extent, increased serum TIBC. Histopathology of liver shows macro fatty changes, vacuolization, marked necrosis, severe degenerative changes, while kidney shows cell infiltration. All these changes were significantly attenuated by administration of Dadimadi yoga. Hence, it can be concluded that Dadimadi yoga is having significant hematinic as well as cytoprotective activity.
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